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CQ and PDTC Spontaneously React with Basic Copper Chloride to Form a New Complex
Adaugat pe 12/08/2019 11:36:28 de weishida

In order to use endogenous elevated tumor copper as a targeting
mechanism for breast cancer therapy, it is necessary that the ligand under
consideration be capable of reacting spontaneously with copper to form a new
complex. Complex formation reactions, particularly those involving metal, can
result in dramatic color changes and/or precipitate formation. To test the
reactivity of CQ and PDTC with copper, 50 mM of each was added to a 50 mM
solution of Basic
Copper Chloride
. The reaction of CQ and PDTC with copper, in DMSO,
results in a dramatic color change, indicating a chemical reaction has occurred
and a metal complex has formed. These results are consistent with previous
publications showing that both CQ and PDTC are strong copper chelators.
Therefore, these ligands may be capable of combining with endogenous tumor
copper and forming a reactive complex.

The CQ-copper mixture has been further examined by the advanced
photon source (APS) of Argonne National Laboratories. The result is consistent
with formation of a new complex between CQ and copper in solution. Furthermore,
samples of a PDTC-copper mixture will be analyzed by the APS to confirm complex
formation and the resulting structure. The details of these studies will be
presented in a future manuscript.

Wujiang Weishida Copper Technology Co.,Ltd. has 12,000 square
meters of production base. By virtue of their sincere cooperation, reciprocity
of the business philosophy for the industry users around the country to provide
high-quality non-ferrous metal products. Weishida specializes in producing
cuprous chloride, basic copper carbonate, copper acetate, copper oxide, copper
sulfate. Our company has established a perfect quality assurance system, quality
inspection and testing equipment, testing, testing and technology development
strength, to ensure the stability of product quality, fully able to meet the
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Tag-uri: Basic Copper Chloride

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